After Sam and Dean witness their mother's paranormal death as children they grow up trained to fight by their distraught father who is on the trail of the demon.
Supernatural is a really good entry into genre television, with Season 2 providing a lot of the groundwork that allows the series to earn such a label.
The initial story units - Dean dealing with guilt and death of John and establishing the Roadhouse - work well, and I'm eager to see how the show develops these concepts and also introduces new ones.