In order to unveil his new invent that can change humanity and helps him to gain fame and wealth, an ambitious scientist Dr. Rusty Venture, accompanies his enthusiastic sons and his guard to New York for that purpose, where they struggle against facing the evil who do their best, in order to steal his invention.
Beginning as a relatively straightforward Johnny Quest parody, over the course of its first two seasons The Venture Bros. developed a mythology as deep and rewarding as that of the comic books and sci-fi series that it was spoofing.