The show's humour relies on a certain hyper-specificity both in its characters and its setting, and it's a testament to the fine writing and vocal performances that all this is bedded in by the end of the first episode, more or less...
With memorable characters, running credit gags and catchy episode-closing songs, I don't think Bob's Burgers as reimagined by somebody who just watched Northern Exposure would be such a bad thing anyway.