It is a series of action-related events and the friendships of three EMT paramedics in Chicago. In that series, these people encounter unusual situations in that period that are often terrible or humorous. It seems that these people do hard work and stand up for the interests of those people who need their help.
At its best is dumb fun. Johnny, Hank and rookie EMT Brian of course keep making a fine mess of things. They also mesh together pretty well in a series that bracingly is without a detracting laugh track.
There's more going on in Sirens than the vast bulk of what other cable comedies are offering and more than 50 percent of network sitcoms (where, let's not kid ourselves, the quality is actually higher than on cable).