In this film, it appears that there is a new drug that leads to a different path through experiences outside the body, but users go back to eternity, and another global invasion of Earth takes place. Perhaps in the end, two college dropouts could save humanity from an invasion that could reverse the course of things.
The saving grace of John Dies at the End is undoubtedly its manic storytelling: the energy and pacing of scenes give the movie the impression of being told on the spot (which is of course what the framing device intends).
This is a gloriously gonzo trip packed with enough odd narrative tangents to fill half a dozen features. While not always successful, this energetic mash-up so genuinely wants to entertain that it's hard not to be won over by its barrage of absurdity.