The film starts with a short documentary on Rucker Park Legends. Famed basketball players like Dikembe Mutombo and Steve Nash talk about one of the all-time greats, Uncle Drew (Kyrie Irving). He was exceptionally great at the game and would play with a team of his own, but they split up after Drew allegedly slept with one of his teammates' girlfriends.
In the present, we meet Dax Winslow (Lil Rel Howery), a basketball coach. He is visited by his childhood nemesis Mookie (Nick Kroll), who seeks to take Dax's star player, Casper (Aaron Gordon). Dax tries to appeal to Casper and ask him if he needs anything. Knowing Dax works at a shoe store, he requests a new pair of Jordans sneakers, which Dax says he will secure for Casper once they arrive.