The widow, Deputy Sheriff Jane Kozik, moves from Manhattan to Black Stone, New York, with her daughter Kelsey Kozik. There she expects to find a safe place to live. The day after moving, a homeless man is found dead in the tool shed of Jane's blind friend Beverly Rowe. Devin Hall and the entomologist Katherine Randell are summoned to help with the investigation. Devin is Jane's brother-in-law and former boyfriend, and Jane still has a crush on him. Meanwhile, Kelsey befriends the scientist Eli Giles, who has developed genetically modified wasps for the Army as a weapon, and now he is trying to revert the process. When the wasps attack Black Stone, Jane, Devin, and Eli team-up to attempt to destroy the swarm.
